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Hydroxyapatite/Mesoporous Graphene/Single‐Walled Carbon Nanotubes Freestanding Flexible Hybrid Membranes for Regenerative Medicine
Author(s) -
Zhang Rujing,
Metoki Noah,
SharabaniYosef Orna,
Zhu Hongwei,
Eliaz Noam
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201602088
Subject(s) - materials science , membrane , graphene , biomineralization , nanotechnology , carbon nanotube , simulated body fluid , mesoporous material , nucleation , surface modification , apatite , chemical engineering , composite material , chemistry , scanning electron microscope , biochemistry , organic chemistry , engineering , catalysis
Freestanding flexible membranes based on biocompatible calcium phosphates are of great interest in regenerative medicine. Here, the authors report the first synthesis of well‐aligned biomimetic hexagonal bars of hydroxyapatite (HAp) on flexible, freestanding mesoporous graphene/single‐walled carbon nanotubes (MG/SWCNT) hybrid membranes. The chemical composition and surface morphology of the HAp coating resemble those of biological apatite. Nitrogen doping and oxygen plasma etching of the MG/SWCNT membranes increase the density of nucleation sites and yield more uniform coatings. This novel membrane favors the attachment and proliferation of human fetal osteoblast (hFOB) osteoprogenitor cells. When soaked in simulated body fluid, enhanced in vitro biomineralization occurs on the hybrid membranes. This hybrid membrane holds great promise in biomedical applications such as patches and strips for spine fusion, bone repair, and restoration of tooth enamel.