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Optimization of Prussian Blue Coated NaDyF 4 : x %Lu Nanocomposites for Multifunctional Imaging‐Guided Photothermal Therapy
Author(s) -
Liu Yuxin,
Guo Quanwei,
Zhu Xingjun,
Feng Wei,
Wang Lu,
Ma Liyi,
Zhang Ge,
Zhou Jing,
Li Fuyou
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201601478
Subject(s) - photothermal therapy , materials science , prussian blue , nanocomposite , nanomaterials , magnetic resonance imaging , nanotechnology , nanoparticle , doping , biomedical engineering , optoelectronics , radiology , medicine , chemistry , electrode , electrochemistry
Imaging‐guided photothermal therapy based on functional nanomaterials has recently received significant attention and the selection of functional materials with optimal imaging and therapy effect is extremely important. In this work, NaDyF 4 ‐based nanoparticles with varying size are synthesized by doping with different amounts of lutetium ions. To obtain an optimized material, the influence factor of magnetic resonance, X‐ray attenuation, and photothermal properties are discussed in detail. Then, NaDyF 4 :50%Lu@Prussian blue (PB) nanocomposite is selected as the optimal functional material for T 1 ‐ and T 2 ‐weighted magnetic resonance imaging, X‐ray computed tomography, and photothermal imaging‐guided photothermal therapy of tumor on a small animal model, and the treatment is applied with good results. Studies also suggest that the NaDyF 4 :50%Lu@PB nanocomposites are biocompatibile. The selection of an optimal material from a multi‐perspective study has provided an incentive for the development of an assortment of novel multifunctional materials for early cancer multifunctional diagnosis and imaging‐guided photothermal therapy.