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Multifunctional Carbon–Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo‐Cancer Therapy under the Guidance of Bimodal Imaging
Author(s) -
Li Linlin,
Chen Chuanfang,
Liu Huiyu,
Fu Changhui,
Tan Longfei,
Wang Shunhao,
Fu Shiyan,
Liu Xi,
Meng Xianwei,
Liu Hong
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201600985
Subject(s) - photothermal therapy , nanocapsules , materials science , biocompatibility , nanotechnology , mesoporous silica , nanomaterials , cancer therapy , nanoparticle , doxorubicin , biomedical engineering , cancer , mesoporous material , chemotherapy , medicine , chemistry , catalysis , organic chemistry , surgery , metallurgy
Carbon‐based nanomaterials have been developed for photothermal cancer therapy, but it is still a great challenge to fabricate their multifunctional counterparts with facile methods, good biocompatibility and dispersity, and high efficiency for cancer theranostics. In this work, an alternative multifunctional nanoplatform is developed based on carbon–silica nanocapsules with gold nanoparticle in the cavity (Au@CSN) for cancer theranostics. The encapsulated chemodrug doxorubicin can be released from the Au@CSN with mesoporous and hollow structure in a near‐infrared light and pH stimuli‐responsive manner, facilitating spatiotemporal therapy to decrease off‐target toxicity. The nanocapsules with efficient photothermal conversion and excellent biocompatibility achieve a synergistic effect of photothermal and chemotherapy. Furthermore, the nanocapsules can act as a multimodal imaging agent of computed tomography and photoacoustic tomography imaging for guiding the therapy. This new design platform can provide a promising strategy for precise cancer theranostics.