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Photodynamic Therapy: Light‐Up Probe for Targeted and Activatable Photodynamic Therapy with Real‐Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses (Adv. Funct. Mater. 42/2015)
Author(s) -
Yuan Youyong,
Zhang ChongJing,
Kwok Ryan T. K.,
Xu Shidang,
Zhang Ruoyu,
Wu Jien,
Tang Ben Zhong,
Liu Bin
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570273
Subject(s) - photodynamic therapy , photosensitizer , materials science , apoptosis , fluorescence , programmed cell death , cancer research , biophysics , in situ , photochemistry , nanotechnology , optics , medicine , chemistry , biochemistry , biology , physics , organic chemistry
On page 6586, B. Z. Tang, B. Liu and co‐workers synthesize a photosensitizer (PS) probe with a built‐in apoptosis sensor for targeted cancer cell ablation and real‐time monitoring of PS activation and therapeutic response. The probe is non‐emissive in aqueous media, and, when selectively taken up by cancer cells, can be cleaved to release the apoptosis sensor, turning on red fluorescence. Upon light irradiation cell apoptosis is induced, and the apoptosis sensor is cleaved to yield intense green fluorescence.