Gene Delivery: Nano‐Self‐Assembly of Nucleic Acids Capable of Transfection without a Gene Carrier (Adv. Funct. Mater. 34/2015) | Zendy

Lim Kwang Suk | Zendy; Lee Daniel Y. | Zendy; Valencia Gabriel M. | Zendy; Won YoungWook | Zendy; Bull David A. | Zendy

Premium

Gene Delivery: Nano‐Self‐Assembly of Nucleic Acids Capable of Transfection without a Gene Carrier (Adv. Funct. Mater. 34/2015)

Author(s) -

Lim Kwang Suk,

Lee Daniel Y.,

Valencia Gabriel M.,

Won YoungWook,

Bull David A.

Publication year - 2015

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.201570229

Subject(s) - nucleic acid , transfection , internalization , endocytosis , materials science , dna , gene delivery , nano , nanotechnology , gene , biophysics , cell , biology , biochemistry , composite material

On page 5445, Y.‐W. Won, D. A. Bull, and co‐workers show that Zn 2+ is able to assemble nucleic acids into a nanocluster that is capable of spontaneous internalization into cells. Zn 2+ shows superior gene transfection efficiency among the three divalent metal ions tested. Various endocytosis mechanisms are involved in the cellular uptake of the Zn/DNA cluster.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research