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Gene Delivery: Nano‐Self‐Assembly of Nucleic Acids Capable of Transfection without a Gene Carrier (Adv. Funct. Mater. 34/2015)
Author(s) -
Lim Kwang Suk,
Lee Daniel Y.,
Valencia Gabriel M.,
Won YoungWook,
Bull David A.
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570229
Subject(s) - nucleic acid , transfection , internalization , endocytosis , materials science , dna , gene delivery , nano , nanotechnology , gene , biophysics , cell , biology , biochemistry , composite material
On page 5445, Y.‐W. Won, D. A. Bull, and co‐workers show that Zn 2+ is able to assemble nucleic acids into a nanocluster that is capable of spontaneous internalization into cells. Zn 2+ shows superior gene transfection efficiency among the three divalent metal ions tested. Various endocytosis mechanisms are involved in the cellular uptake of the Zn/DNA cluster.