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Biomimetic Sensors: Vectorially Imprinted Hybrid Nanofilm for Acetylcholinesterase Recognition (Adv. Funct. Mater. 32/2015)
Author(s) -
Jetzschmann Katharina J.,
Jágerszki Gyula,
Dechtrirat Decha,
Yarman Aysu,
GajovicEichelmann Nenad,
Gilsing HansDetlev,
Schulz Burkhard,
Gyurcsányi Róbert E.,
Scheller Frieder W.
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570215
Subject(s) - acetylcholinesterase , molecularly imprinted polymer , materials science , selectivity , nanotechnology , biophysics , enzyme , biochemistry , biology , catalysis
On page 5178, R. E. Gyurcsányi, F. W. Scheller, and co‐workers demonstrate specific recognition of acetylcholinesterase, a potential marker of Alzheimer's disease, by a hybrid material which shows threefold selectivity gain by the “shape‐specific” electrosynthesized molecularly imprinted polymer, oriented binding to the propidium layer and signal generation exclusively by the enzyme bound to the nanofilm. Acetylcholinesterase is detected in the nanomolar range, whilst interfering proteins are effectively suppressed.