Premium
Gene Delivery: Tumor Intracellular‐Environment Responsive Materials Shielded Nano‐Complexes for Highly Efficient Light‐Triggered Gene Delivery without Cargo Gene Damage (Adv. Funct. Mater. 23/2015)
Author(s) -
Park Sinjung,
Park Wooram,
Na Kun
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570155
Subject(s) - gene delivery , materials science , drug delivery , gene expression , extracellular , gene , intracellular , nanotechnology , nano , penetration (warfare) , biophysics , microbiology and biotechnology , genetic enhancement , biochemistry , biology , composite material , engineering , operations research
On page 3472, K. Na and co‐workers report highly efficient photo‐triggered gene expression without damage to the gene from reactive oxygen species by taking advantage of the endo‐lysosomal pH‐sensitive de‐shielding ability of the pH‐responsive shielding material incorporated in the gene complexes. Importantly, this newly developed gene delivery system also resolves the tissue penetration issue in drug delivery systems by photo‐mediated breaking down the extracellular matrix.