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Micelles: pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer (Adv. Funct. Mater. 17/2015)
Author(s) -
Yu Haijun,
Cui Zhirui,
Yu Pengcheng,
Guo Chengyue,
Feng Bing,
Jiang Tongying,
Wang Siling,
Yin Qi,
Zhong Dafang,
Yang Xiangliang,
Zhang Zhiwen,
Li Yaping
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570112
Subject(s) - micelle , doxorubicin , materials science , multiple drug resistance , penetration (warfare) , hyperthermia , cancer cell , lysosome , drug delivery , cancer research , pharmacology , drug resistance , medicine , cancer , nanotechnology , chemotherapy , chemistry , biology , microbiology and biotechnology , biochemistry , organic chemistry , operations research , aqueous solution , enzyme , engineering
On page 2489 H. Yu, Y. Li, and co‐workers report a pH and near‐infrared light responsive micelle for combating cancer multidrug resistance (MDR). The micelles induce moderate hyperthermia effect upon NIR laser illumination to facilitate their tumor penetration and lysosome escape, thus improving the therapeutic efficacy of doxorubicin. This study implies a novel strategy for treatment of MDR cancer.