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Hybrid Nanoparticles: Design of Hybrid MnO 2 ‐Polymer‐Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment (Adv. Funct. Mater. 12/2015)
Author(s) -
Gordijo Claudia R.,
Abbasi Azhar Z.,
Amini Mohammad Ali,
Lip Ho Yin,
Maeda Azusa,
Cai Ping,
O'Brien Peter J.,
DaCosta Ralph S.,
Rauth Andrew M.,
Wu Xiao Yu
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570087
Subject(s) - nanoparticle , materials science , polymer , tumor microenvironment , nanotechnology , oxygen , cancer , chemical engineering , organic chemistry , medicine , chemistry , composite material , engineering
On page 1858, X. Y. Wu and co‐workers present new hybrid MnO 2 nanoparticles with controllable O 2 generation rates by tailoring the hydrophobicity and structure of the polymer and lipid‐based carrier system. The nanoparticles preferentially react with endogenous H 2 O 2 in the tumor providing sustained O 2 generation. The nanoparticles are demonstrated to be safe for intravenous administration, show superior tumor accumulation and retention, and are able to decrease tumor hypoxia and regulate the tumor microenvironment for improving cancer treatment. (Illustration by David Liang.)