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Gene Therapy: Magnetic Helical Microswimmers Functionalized with Lipoplexes for Targeted Gene Delivery (Adv. Funct. Mater. 11/2015)
Author(s) -
Qiu Famin,
Fujita Satoshi,
Mhanna Rami,
Zhang Li,
Simona Benjamin R.,
Nelson Bradley J.
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570080
Subject(s) - gene delivery , materials science , nanotechnology , genetic enhancement , plasmid , biophysics , in vitro , dna , gene , chemistry , biology , biochemistry
Magnetic helical microswimmers, called artificial bacterial flagella (ABFs), can perform precise 3D navigation in liquids under low‐strength rotating magnetic fields (<10 mT), making themselves promising tools for targeted therapies. On page 1666 S. Fijuta, B. J. Nelson, and team show that the ABFs are functionalized with lipoplexes containing plasmid DNA, and the successful wirelessly targeted gene delivery to human embryonic kidney cells in vitro using these functionalized ABFs is demonstrated.