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Hydrogels: Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells (Adv. Funct. Mater. 9/2015)
Author(s) -
Cai Lei,
Dewi Ruby E.,
Heilshorn Sarah C.
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570060
Subject(s) - self healing hydrogels , materials science , cell encapsulation , in situ , scaffold , stem cell , tissue engineering , biomedical engineering , transplantation , nanotechnology , polymer chemistry , microbiology and biotechnology , surgery , chemistry , medicine , organic chemistry , biology
S. C. Heilshorn and co‐workers design shear‐thinning hydrogels for injectable encapsulation and long‐term delivery (SHIELD) by combining protein‐engineering and synthetic polymer technologies. On page 1344, stem cell transplantation using SHIELD results in a 400% increase in one‐week cell retention compared to cell delivery in saline, the clinical standard. These materials work by providing a “shield” against cell membrane damage during injection and then stiffening in situ to create a scaffold for cell attachment.