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Drug Delivery: Enzyme‐Responsive Release of Doxorubicin from Monodisperse Dipeptide‐Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro (Adv. Funct. Mater. 8/2015)
Author(s) -
Zhang He,
Fei Jinbo,
Yan Xuehai,
Wang Anhe,
Li Junbai
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201570057
Subject(s) - nanocarriers , materials science , drug delivery , doxorubicin , nanotechnology , drug , glutaraldehyde , nanoparticle , targeted drug delivery , pharmacology , chemistry , organic chemistry , medicine , chemotherapy , surgery
Cationic diphenylalanine can self‐assemble into biocompatible and biodegradable nanoparticles through cross‐linkage of glutaraldehyde. As shown by X. Yan, J. Li, and colleagues on page 1193, such assembled nanoparticles have a typical enzyme‐responsive characterization and can be employed as nanocarriers for drug delivery. The doxorubicin‐loaded nanocarriers with a lower drug concentration still possess a higher efficiency in killing cancer cells.