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Metal‐Organic‐Framework‐Coated Optical Fibers as Light‐Triggered Drug Delivery Vehicles
Author(s) -
Nazari Marziyeh,
RubioMartinez Marta,
Tobias Gerard,
Barrio Jorge Pérez,
Babarao Ravichandar,
Nazari Fatemeh,
Konstas Kristina,
Muir Benjamin W.,
Collins Stephen F.,
Hill Anita J.,
Duke Mikel C.,
Hill Matthew R.
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201505260
Subject(s) - materials science , drug delivery , optical fiber , fiber , nanotechnology , layer (electronics) , anticancer drug , drug , optoelectronics , pharmacology , composite material , optics , medicine , physics
Physical delivery of anticancer drugs in controlled anatomic locations can complement the advances being made in chemo‐selective therapies. To this end, an optical fiber catheter is coated in a thin layer of metal organic framework UiO‐66 and the anticancer drug 5‐Fluorouracil (5‐FU) is deposited within the pores. Delivery of light of appropriate wavelength through the fiber catheter is found to trigger the release of 5‐FU on demand, offering a new route to localized drug administration. The system exhibits great potential with as much as 110 × 10 −6 m of 5‐FU delivered within 1 min from one fiber.