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FeSe 2 ‐Decorated Bi 2 Se 3 Nanosheets Fabricated via Cation Exchange for Chelator‐Free 64 Cu‐Labeling and Multimodal Image‐Guided Photothermal‐Radiation Therapy
Author(s) -
Cheng Liang,
Shen Sida,
Shi Sixiang,
Yi Yuan,
Wang Xiaoyong,
Song Guosheng,
Yang Kai,
Liu Gang,
Barnhart Todd E.,
Cai Weibo,
Liu Zhuang
Publication year - 2016
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201504810
Subject(s) - materials science , photothermal therapy , nanoparticle , nanotechnology , polyethylene glycol , nanostructure , chemical engineering , engineering
Multifunctional theranostic agents have become rather attractive to realize image‐guided combination cancer therapy. Herein, a novel method is developed to synthesize Bi 2 Se 3 nanosheets decorated with mono‐dispersed FeSe 2 nanoparticles (FeSe 2 /Bi 2 Se 3 ) for tetra‐modal image‐guided combined photothermal and radiation tumor therapy. Interestingly, upon addition of Bi(NO 3 ) 3 , pre‐made FeSe 2 nanoparticles via cation exchange would be gradually converted into Bi 2 Se 3 nanosheets, on which remaining FeSe 2 nanoparticles are decorated. The yielded FeSe 2 /Bi 2 Se 3 composite‐nanostructures are then modified with polyethylene glycol (PEG). Taking advantages of the high r 2 relaxivity of FeSe 2 , the X‐ray attenuation ability of Bi 2 Se 3 , the strong near‐infrared optical absorbance of the whole nanostructure, as well as the chelate‐free radiolabeling of 64 Cu on FeSe 2 /Bi 2 Se 3 ‐PEG, in vivo magnetic resonance/computer tomography/photoacoustic/position emission tomography multimodal imaging is carried out, revealing efficient tumor homing of FeSe 2 /Bi 2 Se 3 ‐PEG after intravenous injection. Utilizing the intrinsic physical properties of FeSe 2 /Bi 2 Se 3 ‐PEG, in vivo photothermal and radiation therapy to achieve synergistic tumor destruction is then realized, without causing obvious toxicity to the treated animals. This work presents a unique method to synthesize composite‐nanostructures with highly integrated functionalities, promising not only for nano‐biomedicine but also potentially for other different nanotechnology fields.