Development of a Highly Selective, Sensitive, and Fast Response Upconversion Luminescent Platform for Hydrogen Sulfide Detection

Hydrogen sulfide (H 2 S) has been recognized as one of most important gaseous signaling molecules mediated by a variety of physiological and pathological processes. Yet, its functions remain largely elusive due to the lack of potent monitoring methods. Hereby this issue is addressed with a powerful new platform—dye‐assembled upconversion nanoparticles (UCNPs). A series of chromophores with different absorption bands and fast responses towards H 2 S is combined with UCNPs and results in a library of H 2 S sensors with responsive emission signals ranging from the visible to the near‐infrared (NIR) region. These nanoprobes demonstrate highly selective and rapid responses to H 2 S in vitro and in cells. Furthermore, H 2 S levels in blood can be detected using the developed nanoprobes. Hence the reported H 2 S sensing platform can serve as a powerful diagnostic tool to research H 2 S functions and to investigate H 2 S‐related diseases.