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Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System
Author(s) -
Zhang Guilong,
Du Ruohong,
Zhang Lele,
Cai Dongqing,
Sun Xiao,
Zhou Yong,
Zhou Jian,
Qian Junchao,
Zhong Kai,
Zheng Kang,
Kaigler Darnell,
Liu Wenqing,
Zhang Xin,
Zou Duohong,
Wu Zhengyan
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201502868
Subject(s) - nanoprobe , drug delivery , materials science , doxorubicin , magnetic resonance imaging , gadolinium , folate receptor , in vivo , internalization , targeted drug delivery , cancer research , cytotoxicity , cancer , cancer cell , biophysics , in vitro , nuclear magnetic resonance , nanoparticle , nanotechnology , medicine , cell , chemotherapy , chemistry , biochemistry , radiology , biology , microbiology and biotechnology , metallurgy , physics
In this study, a high‐performance T 1 – T 2 dual‐model contrast agent by gadolinium‐doped iron oxide nanoparticle (GION) is developed. Following its development, the application of this agent in vivo by combining doxorubicin (DOX) and folic acid (FA) (FA–GION–DOX) for targeted drug delivery to monitor cancer treatment is explored. GION showed transverse and longitudinal relaxivities up to 182.7 × 10 −3 and 7.87 × 10 −3 m −1 s −1 , respectively, upon Gd/Fe ratio in GION at 1/4. DOX released from FA–GION–DOX is pH dependent and only kills cancer cell after FA receptor‐mediated internalization into the acidic environment of endosomes and lysosomes. Systemic delivery of FA–GION–DOX significantly inhibits the growth of tumors and shows good magnetic resonance enhancement in a human cervical cancer xenograft model. Thus, FA–GION–DOX has a potential application for the targeted and magnetic resonance imaging guided therapy of cervical cancer.