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Imaging‐Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine‐131‐Doped Copper Sulfide Nanoparticles
Author(s) -
Yi Xuan,
Yang Kai,
Liang Chao,
Zhong Xiaoyan,
Ning Ping,
Song Guosheng,
Wang Dongliang,
Ge Cuicui,
Chen Chunying,
Chai Zhifang,
Liu Zhuang
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201502003
Subject(s) - photothermal therapy , radiation therapy , materials science , in vivo , polyethylene glycol , peg ratio , cancer , cancer research , metastasis , iodine , medicine , biomedical engineering , nanotechnology , radiology , chemistry , biology , metallurgy , microbiology and biotechnology , organic chemistry , finance , economics
Combining different therapeutic strategies to treat cancer by overcoming limitations of conventional cancer therapies has shown great promise in both fundamental and clinical studies. Herein, by adding 131 I when making iodine‐doped CuS nanoparticles, CuS/[ 131 I]I nanoparticles are obtained, which after functionalization with polyethylene glycol (PEG) are used for radiotherapy (RT) and photothermal therapy (PTT), by utilizing their intrinsic high near‐infrared absorbance and the doped 131 I‐radioactivity, respectively. The combined RT and PTT based on CuS/[ 131 I]I‐PEG is then conducted, achieving remarkable synergistic therapeutic effects as demonstrated in the treatment of subcutaneous tumors. In the meanwhile, as revealed by bimodal nuclear imaging and computed tomography (CT) imaging, it is found that CuS/[ 131 I]I‐PEG nanoparticles after being injected into primary solid tumors could migrate to and retain in their nearby sentinel lymph nodes. Importantly, the combined RT and PTT applied on those lymph nodes to assist surgical resection of primary tumors results in remarkably inhibited cancer metastasis and greatly prolonged animal survival. In vivo toxicology studies further reveal that our CuS/I‐PEG is not obviously toxic to animals at fourfold of the treatment dose. This work thus demonstrates the potential of combining RT and PTT using a single nanoagent for imaging‐guided treatment of metastatic tumors.