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Mussel‐Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy
Author(s) -
GhavamiNejad Amin,
Sasikala Arathyram Ramachandra Kurup,
Unnithan Afeesh Rajan,
Thomas Reju George,
Jeong Yong Yeon,
VatankhahVarnoosfaderani Mohammad,
Stadler Florian J.,
Park Chan Hee,
Kim Cheol Sang
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201500389
Subject(s) - nanofiber , catechol , bortezomib , materials science , drug delivery , combinatorial chemistry , prodrug , photothermal therapy , nanotechnology , biophysics , organic chemistry , biochemistry , chemistry , multiple myeloma , biology , immunology
A method for the versatile synthesis of novel, mussel‐inspired, electrospun nanofibers with catechol moieties is reported. These mussel‐inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate‐containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2‐benzenediol (catechol) moieties for enabling a pH‐dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel‐inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug‐bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.