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Theranostics: Polymer‐Coated Radioluminescent Nanoparticles for Quantitative Imaging of Drug Delivery (Adv. Funct. Mater. 37/2014)
Author(s) -
Moore Thomas L.,
Wang Fenglin,
Chen Hongyu,
Grimes Stuart W.,
Anker Jeffrey N.,
Alexis Frank
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201470247
Subject(s) - materials science , nanoparticle , protoporphyrin ix , drug delivery , absorption (acoustics) , nanotechnology , polymer , drug , photodynamic therapy , chemistry , organic chemistry , pharmacology , medicine , composite material
F. Alexis and co‐workers use X‐ray excited optical luminescent nanoparticles (XEOL NPs) to quantitatively measure intracellular drug release. On page 5815, XEOL NPs or radioluminescent NPs, are loaded with the photoactive drug protoporphyrin IX (PpIX). The overlap between the XEOL NP emission and the PpIX absorption enables a quantitative approach to measure drug loading and release kinetics in both buffer solution and into cells.