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Targeted Chemotherapy: Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide and Acid‐Responsive Antitumor Drug (Adv. Funct. Mater. 34/2014)
Author(s) -
Zhao Li,
Xu YongHong,
Qin Hongmei,
Abe Shigeaki,
Akasaka Tsukasa,
Chano Tokuhiro,
Watari Fumio,
Kimura Takahide,
Komatsu Naoki,
Chen Xiao
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201470225
Subject(s) - prodrug , nanodiamond , materials science , drug , peptide , combinatorial chemistry , drug delivery , nanotechnology , pharmacology , biochemistry , chemistry , medicine , diamond , composite material
On page 5348, N. Komatsu, X. Chen, and colleagues demonstrate multifunctional anticancer prodrug consisting of nanodiamond core, polyglycerol coating, targeting peptide and platinum‐based drugs. The resulting good aqueous solubility, stealth nature, and targeting property enable the nanodiamond‐based prodrug to be taken up selectively by cancer cells overexpressing αvβ3 integrin and to cause the selective cell death through acid‐responsive drug release.