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Magnetic Nanoparticles: Hierarchically Structured Magnetic Nanoconstructs with Enhanced Relaxivity and Cooperative Tumor Accumulation (Adv. Funct. Mater. 29/2014)
Author(s) -
Gizzatov Ayrat,
Key Jaehong,
Aryal Santosh,
Ananta Jeyarama,
Cervadoro Antonio,
Palange Anna Lisa,
Fasano Matteo,
Stigliano Cinzia,
Zhong Meng,
Di Mascolo Daniele,
Guven Adem,
Chiavazzo Eliodoro,
Asinari Pietro,
Liu Xuewu,
Ferrari Mauro,
Wilson Lon J.,
Decuzzi Paolo
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201470189
Subject(s) - materials science , nanoparticle , superparamagnetism , nanotechnology , polymer , mesoporous material , magnetic nanoparticles , iron oxide , magnetic field , composite material , magnetization , physics , biochemistry , chemistry , quantum mechanics , metallurgy , catalysis
Nanoconstructs are realized by P. Decuzzi and co‐workers by confining ultra‐small (5 nm) superparamagnetic iron oxide nanoparticles (USPIOs) within two different mesoporous structures (silicon and polymers). On page 4584, they exhibit transversal relaxivities up to around 10 times higher than conventional USPIOs and, under external magnetic fields, collectively cooperate to amplify tumor accumulation in mice to provide an MRI contrast enhancement at much smaller doses of iron as compared to current practice.