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Drug Delivery: Polylactide‐ block ‐Polypeptide‐ block ‐Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release (Adv. Funct. Mater. 26/2014)
Author(s) -
Dorresteijn Robert,
Billecke Nils,
Schwendy Mischa,
Pütz Sabine,
Bonn Mischa,
Parekh Sapun H.,
Klapper Markus,
Müllen Klaus
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201470171
Subject(s) - materials science , polymer , nanoparticle , copolymer , drug delivery , cleavage (geology) , peptide , drug , nanotechnology , enzyme , biophysics , biochemistry , chemistry , composite material , psychology , psychiatry , fracture (geology) , biology
In tumor cells, enzyme‐triggered drug release from a nanoparticle after polymer cleavage is demonstrated by S. H. Parekh, M. Klapper, and co‐workers on page 4026. The polymers within the particles contain a specific peptide sequence which is recognized and subsequently cleaved by matrix‐metalloproteinase‐2, an enzyme overexpressed in tumor tissues. The higher mobility of polymer fragments finally leads to drug release and associated cytotoxicity.