Premium
Drug Delivery: Dendron‐Based Micelles for Topical Delivery of Endoxifen: A Potential Chemo‐Preventive Medicine for Breast Cancer (Adv. Funct. Mater. 17/2014)
Author(s) -
Yang Yang,
Pearson Ryan M.,
Lee Oukseub,
Lee ChanWoo,
Chatterton Robert T.,
Khan Seema A.,
Hong Seungpyo
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201470109
Subject(s) - dendrimer , drug delivery , materials science , micelle , permeation , drug , nanotechnology , pharmacology , medicine , organic chemistry , chemistry , polymer chemistry , biochemistry , membrane , aqueous solution
Surface‐modified dendron micelles (DMs) are developed on page 2442 by Seungpyo Hong and colleagues as a potential platform for topical delivery of endoxifen (EDX). The data indicates that skin permeation of EDX is highly dependent on the surface group of the DMs. In particular, carboxylated DMs exhibit significantly enhanced permeation of EDX through both mouse and human skin layers, offering a potential alternative administration route for chemoprevention.