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Porous Silicon Nanodiscs for Targeted Drug Delivery
Author(s) -
Alhmoud Hashim,
Delalat Bahman,
Elnathan Roey,
CifuentesRius Anna,
Chaix Arnaud,
Rogers MaryLouise,
Durand JeanOlivier,
Voelcker Nicolas H.
Publication year - 2015
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201403414
Subject(s) - nanotechnology , camptothecin , porous silicon , materials science , nanocarriers , drug delivery , surface modification , nanoparticle , etching (microfabrication) , silicon , chemistry , layer (electronics) , organic chemistry , metallurgy
There is a strong demand for techniques that allow the fabrication of biocompatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size‐ and shape‐controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal‐assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus‐prepared nanocarriers are found to selectively attach to and kill cancer cells.