z-logo
Premium
Covalent Functionalization of Multi‐walled Carbon Nanotubes with a Gadolinium Chelate for Efficient T 1 ‐Weighted Magnetic Resonance Imaging
Author(s) -
Marangon Iris,
MénardMoyon Cécilia,
KolosnjajTabi Jelena,
Béoutis Marie Lys,
Lartigue Lénaic,
Alloyeau Damien,
Pach Elzbieta,
Ballesteros Belén,
Autret Gwennhael,
Ninjbadgar Tsedev,
Brougham Dermot F.,
Bianco Alberto,
Gazeau Florence
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201402234
Subject(s) - gadolinium , materials science , mri contrast agent , magnetic resonance imaging , chelation , carbon nanotube , surface modification , covalent bond , nuclear magnetic resonance , ligand (biochemistry) , in vivo , drug delivery , photothermal therapy , nanotechnology , biophysics , biomedical engineering , chemistry , organic chemistry , medicine , biochemistry , physics , receptor , microbiology and biotechnology , biology , metallurgy , radiology
Given the promise of carbon nanotubes (CNTs) for photothermal therapy, drug delivery, tissue engineering, and gene therapy, there is a need for non‐invasive imaging methods to monitor CNT distribution and fate in the body. In this study, non‐ionizing whole‐body high field magnetic resonance imaging (MRI) is used to follow the distribution of water‐dispersible non‐toxic functionalized CNTs administrated intravenously to mice. Oxidized CNTs are endowed with positive MRI contrast properties by covalent functionalization with the chelating ligand diethylenetriaminepentaacetic dianhydride (DTPA), followed by chelation to Gd 3+ . The structural and magnetic properties, MR relaxivities, cellular uptake, and application for MRI cell imaging of Gd‐CNTs in comparison to the precursor oxidized CNTs are evaluated. Despite the intrinsic T 2 contrast of oxidized CNTs internalized in macrophages, the anchoring of paramagnetic gadolinium onto the nanotube sidewall allows efficient T 1 contrast and MR signal enhancement, which is preserved after CNT internalization by cells. Hence, due to their high dispersibility, Gd‐CNTs have the potential to produce positive contrast in vivo following injection into the bloodstream. The uptake of Gd‐CNTs in the liver and spleen is assessed using MRI, while rapid renal clearance of extracellular Gd‐CNTs is observed, confirming the evidences of other studies using different imaging modalities.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here