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Photoacoustic Imaging Guided Near‐Infrared Photothermal Therapy Using Highly Water‐Dispersible Single‐Walled Carbon Nanohorns as Theranostic Agents
Author(s) -
Chen Daiqin,
Wang Chao,
Nie Xin,
Li Shumu,
Li Ruimin,
Guan Mirong,
Liu Zhuang,
Chen Chunying,
Wang Chunru,
Shu Chunying,
Wan Lijun
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201401560
Subject(s) - photothermal therapy , materials science , photoacoustic imaging in biomedicine , biocompatibility , absorption (acoustics) , peg ratio , in vivo , nanotechnology , ethylene glycol , near infrared spectroscopy , biomedical engineering , chemical engineering , composite material , optics , medicine , physics , microbiology and biotechnology , engineering , finance , economics , metallurgy , biology
The poly(maleic anhydride‐alt‐1‐octadecene‐poly(ethylene glycol)) (C 18 PMH‐PEG) modified single‐walled carbon nanohorns (SWNHs) are designed with high stability and biocompatibility. The as‐prepared SWNHs/C 18 PMH‐PEG not only can serve as an excellent photothermal agent but also can be used as a promising photoacoustic imaging (PAI) agent both in vitro and in vivo due to its strong absorption in the near infrared (NIR) region. The PAI result reveals that the SWNHs/C 18 PMH‐PEG possesses ultra long blood circulation time and can significantly be accumulated at the tumor site through the enhanced penetration and retention (EPR) effect. The maximum accumulation of SWNHs/C 18 PMH‐PEG at tumor site could be achieved at the time point of 24 h after intravenous injection, which is considered to be the optimal time for the 808 nm laser treatment. The subsequent photothermal ablation of tumors can be achieved without triggering any side effects. Therefore, a PAI guided PTT platform based on SWNHs is proposed and highlights the potential theranostic application for biomedical uses.