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Engineering of Multifunctional Nano‐Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging
Author(s) -
Gong Hua,
Dong Ziliang,
Liu Yumeng,
Yin Shengnan,
Cheng Liang,
Xi Wenyao,
Xiang Jian,
Liu Kai,
Li Yonggang,
Liu Zhuang
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201401451
Subject(s) - photothermal therapy , photodynamic therapy , materials science , photoacoustic imaging in biomedicine , photosensitizer , micelle , nanotechnology , in vivo , biomedical engineering , absorbance , fluorescence lifetime imaging microscopy , magnetic resonance imaging , nanomedicine , fluorescence , nanoparticle , medicine , chemistry , optics , radiology , photochemistry , physics , organic chemistry , aqueous solution , biology , microbiology and biotechnology , chromatography
The integration of diagnostic and therapeutic functionalities on a single theranostic nano‐system holds great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy. Herein, a multifunctional polymeric nano‐micelle system that contains a photosensitizer chlorin e6 (Ce6) is successfully fabricated, at the same time serving as a chelating agent for Gd 3+ , together with a near‐infrared (NIR) dye, IR825. With a r 1 relativity 7 times higher than that of the commercial agent Magnevist, strong fluorescence offered by Ce6, and high NIR absorbance attributed to IR825, these theranostic micelles can be utilized as a contrast agent for triple modal magnetic resonance (MR), fluorescence, and photoacoustic imaging of tumors in a mouse model. The combined photothermal and photodynamic therapy is then carried out, achieving a synergistic anti‐tumor effect both in vitro and in vivo. Different from single photo treatment modalities which only affect the superficial region of the tumor under mild doses, the combination therapy at the same dose using this agent is able to induce significant damage to both superficial and deep parts of the tumor. Therefore, this work presents a polymer based theranostic platform with great potential in multimodal imaging and combination therapy of cancer.