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Influence of Direct Laser Written 3D Topographies on Proliferation and Differentiation of Osteoblast‐Like Cells: Towards Improved Implant Surfaces
Author(s) -
Hohmann Judith K.,
von Freymann Georg
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201401390
Subject(s) - materials science , osteoblast , alkaline phosphatase , adhesion , morphology (biology) , titanium , implant , microstructure , nanotechnology , composite material , in vitro , metallurgy , biology , biochemistry , enzyme , medicine , genetics , surgery
The influence of truly three‐dimensional microstructures on osteoblast‐like cells is reported. Well defined templates are fabricated by direct laser writing and biocompatibly coated with titanium dioxide, resembling implant surfaces. The influence of structural parameters on proliferation, morphology, adhesion, and differentiation is studied. A significantly higher proliferation (170%) is observed on particular topographies compared to unstructured surfaces. Additionally, an influence of structural parameters on the morphology of osteoblast‐like cells is obtained, whereas all cells possess the osteoblastic marker alkaline phosphatase within all structures.