Premium
Nanometric Micelles with Photo‐Triggered Cytotoxicity
Author(s) -
Anilkumar Parambath,
Gravel Edmond,
Theodorou Ioanna,
Gombert Karine,
Thézé Benoit,
Ducongé Frédéric,
Doris Eric
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201400840
Subject(s) - micelle , polyethylene glycol , amphiphile , materials science , cytotoxicity , peg ratio , cleavage (geology) , biophysics , derivative (finance) , in vitro , photochemistry , organic chemistry , copolymer , chemistry , biochemistry , aqueous solution , polymer , biology , finance , fracture (geology) , economics , financial economics , composite material
The development of a photo‐responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo‐labile nitrobenzyl group. The resulting amphiphilic units are self‐assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo‐irradiation, micelles undergo cleavage and yield a cytotoxic nitrosobenzaldehyde derivative, which significantly inhibits the proliferation of MDA‐MB‐231 cells under standard in vitro conditions.