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Nanoporous Hydrogen Bonded Polymeric Microparticles: Facile and Economic Production of Cross Presentation Promoting Vaccine Carriers
Author(s) -
Dierendonck Marijke,
Fierens Kaat,
De Rycke Riet,
Lybaert Lien,
Maji Samarendra,
Zhang Zhiyue,
Zhang Qilu,
Hoogenboom Richard,
Lambrecht Bart N.,
Grooten Johan,
Remon Jean Paul,
De Koker Stefaan,
De Geest Bruno G.
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201400763
Subject(s) - nanoporous , tannic acid , materials science , nanotechnology , polymer , in vitro , immune system , self healing hydrogels , chemistry , immunology , biology , biochemistry , polymer chemistry , organic chemistry , composite material
Nanoporous microparticles are produced in a single step based on hydrogen bonding between a neutral polymer and tannic acid. These particles are stable in physiological medium, are non‐toxic to in vitro cultured cells, and can efficiently encapsulate proteins. In vitro and in vivo experiments show that these porous hydrogen bonded microparticles are able to induce antigen‐specific cellular and humoral immune responses against encapsulated vaccine antigens. Considering the easy and low cost manufacturing of this dry powder formulation from approved readily available components, it is anticipated that this technology holds great promise for the formulation of vaccines for developing countries or for pandemic vaccines where long term storage under refrigerated conditions is a major issue. Additionally, due to the versatility of the approach facilitates straightforward co‐encapsulation of a wide variety of additional components to further modulate the immune response.