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Multifunctional Graphene Oxide‐based Triple Stimuli‐Responsive Nanotheranostics
Author(s) -
Chen Yu,
Xu Pengfei,
Shu Zhu,
Wu Meiying,
Wang Lianzhou,
Zhang Shengjian,
Zheng Yuanyi,
Chen Hangrong,
Wang Jin,
Li Yaping,
Shi Jianlin
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201400221
Subject(s) - materials science , graphene , nanotechnology , stacking , superparamagnetism , magnetic hyperthermia , magnetic resonance imaging , nanoparticle , magnetic nanoparticles , chemistry , magnetic field , medicine , magnetization , physics , organic chemistry , quantum mechanics , radiology
Construction of multifunctional stimuli‐responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on‐demand drug release and improved diagnostic imaging to mitigate the side‐effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple‐functional stimuli‐responsive nanosystem based on the co‐integration of superparamagnetic Fe 3 O 4 and paramagnetic MnO x nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH‐responsive drug releasing performance. The integrated MnO x NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH‐responsive and reduction‐triggered T 1 ‐weighted magnetic resonance imaging (MRI). Superparamagnetic Fe 3 O 4 NPs can not only function as the T 2 ‐weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO‐based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis‐related proteins, and anticancer drug‐loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells.