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Tissue Engineering: Composite Three‐Dimensional Woven Scaffolds with Interpenetrating Network Hydrogels to Create Functional Synthetic Articular Cartilage (Adv. Funct. Mater. 47/2013)
Author(s) -
Liao IChien,
Moutos Franklin T.,
Estes Bradley T.,
Zhao Xuanhe,
Guilak Farshid
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370250
Subject(s) - materials science , composite material , self healing hydrogels , scaffold , composite number , ultimate tensile strength , cartilage , tissue engineering , toughness , interpenetrating polymer network , fiber , biomedical engineering , polymer , polymer chemistry , anatomy , medicine
A 3D woven fiber scaffold infiltrated with an interpenetrating network hydrogel mimics the load‐bearing and tribological properties of native cartilage. The woven fiber scaffold, created by X. Zhao, F. Guilak, and co‐workers on page 5833 , provides controlled tensile and compressive mechanical properties in three dimensions, while the infused hydrogel, consisting of an interpenetrating network of alginate and polyacrylamide, provides high toughness and a low coeffecient of friction. This biomimetic, fiber‐reinforced composite structure has potential as an acellular or cell‐based replacement for cartilage.