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Micropatterning: Regulation of Stem Cell Fate in a Three‐Dimensional Micropatterned Dual‐Crosslinked Hydrogel System (Adv. Funct. Mater. 38/2013)
Author(s) -
Jeon Oju,
Alsberg Eben
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370241
Subject(s) - micropatterning , materials science , self healing hydrogels , regenerative medicine , stem cell , tissue engineering , chondrogenesis , nanotechnology , dual (grammatical number) , adipose tissue , biomedical engineering , microbiology and biotechnology , polymer chemistry , chemistry , biology , biochemistry , medicine , art , literature
3D, dual‐crosslinked, oxidized hydrogels with spatially tunable physical properties are micropatterned on page 4765 by O. Jeon and E. Alsberg. Photoencapsulated human adipose‐derived stem cell proliferation rate and osteogenic and chondrogenic differentiation are found to be functions of the micropattern size. The physical properties in this system therefore introduce a new parameter for regulating various cellular behaviors, and a novel platform for studying the proliferation and differentiation of stem cells in a spatially controlled manner for tissue engineering and regenerative medicine applications.