Premium
Biomedical Applications: Liver‐Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination (Adv. Funct. Mater. 44/2013)
Author(s) -
Min Hyun Su,
Son Sejin,
Lee Tae Woong,
Koo Heebeom,
Yoon Hong Yeol,
Na Jin Hee,
Choi Yongseok,
Park Jae Hyung,
Lee Jaeyoung,
Han Moon Hee,
Park RangWoon,
Kim InSan,
Jeong Seo Young,
Rhee Kyehan,
Kim Sun Hwa,
Kwon Ick Chan,
Kim Kwangmeyung
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370223
Subject(s) - echogenicity , materials science , hyaluronic acid , nanoparticle , microbubbles , nanotechnology , in vivo , ultrasound , imaging phantom , biomedical engineering , biophysics , radiology , anatomy , biology , medicine , microbiology and biotechnology
On page 5518 , an ultralong‐acting, liver‐specific, ultrasound contrast agent is presented in the form of self‐assembled, echogenic hyaluronic acid nanoparticles. I. C. Kwon, K. Kim, and co‐workers use hydrophobic interactions and an oilin‐water emulsification method to encapsulate bioinert and hydrophobic perfluoropentane as an ultrasound gas precursor into the nanoparticles. These particles are more stable and robust echogenic solid bodies than the conventional microbubbles, with an in vivo favorable hydrodynamic size.