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Hydrogels: Remote‐Controlled Hydrogel Depots for Time‐Scheduled Vaccination (Adv. Funct. Mater. 43/2013)
Author(s) -
Gübeli Raphael J.,
Hövermann Désirée,
Seitz Hanna,
Rebmann Balder,
Schoenmakers Ronald G.,
Ehrbar Martin,
CharpinEl Hamri Ghislaine,
DaoudEl Baba Marie,
Werner Martin,
Müller Martin,
Weber Wilfried
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370218
Subject(s) - materials science , self healing hydrogels , controlled release , dissolution , nanotechnology , biomedical engineering , chemical engineering , medicine , polymer chemistry , engineering
W. Weber and co‐workers present a stimulusresponsive biohybrid material which allows the release of vaccines in a remote‐controlled manner in vivo. The orally administered stimulus molecule fluorescein reaches the polyethylene glycolbased depot via the bloodstream, leading to its dissolution and the release of the incorporated vaccine particles. On page 5355 , the applicability of this material is demonstrated in mice by the time‐controlled release of the vaccine from the body finally resulting in successful immunoprotection. The cover image is courtesy of Olaf Baldini.