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Drug Delivery: Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release (Adv. Funct. Mater. 33/2013)
Author(s) -
Zhang Xiao,
Yang Piaoping,
Dai Yunlu,
Ma Ping'an,
Li Xuejiao,
Cheng Ziyong,
Hou Zhiyao,
Kang Xiaojiao,
Li Chunxia,
Lin Jun
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370164
Subject(s) - materials science , nanocomposite , polymer , mesoporous silica , drug delivery , mesoporous material , nanotechnology , fluorescence , smart polymer , nanoparticle , drug , chemical engineering , organic chemistry , composite material , chemistry , optics , psychology , physics , engineering , psychiatry , catalysis
On page 4067 , Z. Cheng, J. Lin, and co‐workers report the synthesis of a multifunctional nanocomposite as an anticancer drug carrier based on a NaYF 4 :Yb 3+ /Er 3+ core and mesoporous silica shell with thermo/pH‐coupled sensitive polymer brushes grafted onto the silica surface as gate molecules. The particles can be used as fluorescent upconverters for cell imaging, and the drug release property can be promoted either by decreasing the pH to match the acidic tumor environment or by NIR laser irradiation.