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Biomedical Applications: Multilayered Blood Capillary Analogs in Biodegradable Hydrogels for In Vitro Drug Permeability Assays (Adv. Funct. Mater. 14/2013)
Author(s) -
Yoshida Hiroaki,
Matsusaki Michiya,
Akashi Mitsuru
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370069
Subject(s) - self healing hydrogels , materials science , capillary action , permeability (electromagnetism) , drug delivery , biomedical engineering , blood vessel , drug , blood capillary , vascular permeability , albumin , human blood , nanotechnology , pharmacology , composite material , chemistry , polymer chemistry , medicine , pathology , biochemistry , circulatory system , membrane , physiology
Multilayered blood capillary analogs are constructed in biodegradable hydrogels as reported by Mitsuru Akashi and co‐workers on page 1736 . The size, orientation, length, layer, and cell type of the artificial blood capillaries are easily controlled. Additionally, permeability control of serum albumin by altering blood vessel cell layers is demonstrated. This technique will be useful as an innovative technology for drug permeability assessment to human blood vessels.