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Drug Delivery: Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination (Adv. Funct. Mater. 2/2013)
Author(s) -
DeMuth Peter C.,
GarciaBeltran Wilfredo F.,
AiLing Michelle Lim,
Hammond Paula T.,
Irvine Darrell J.
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201370008
Subject(s) - adjuvant , materials science , drug delivery , immunization , vaccination , composite number , nanotechnology , delivery system , antigen , biomedical engineering , medicine , immunology , composite material
Skin patches containing micrometer‐scale needles (“microneedles”) provide a safe, convenient, and pain‐free approach for effective delivery of vaccines and pharmaceuticals. Paula T. Hammond, Darrell J. Irvine, and co‐workers report on page 161 the design and use of a composite microneedle architecture for rapid cutaneous delivery and coordinated control over the release of antigen and adjuvant vaccine components for improved immunization in mice.