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Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica‐Coated Au/Fe 2 O 3 Nanoaggregates
Author(s) -
Sotiriou Georgios A.,
Starsich Fabian,
Dasargyri Athanasia,
Wurnig Moritz C.,
Krumeich Frank,
Boss Andreas,
Leroux JeanChristophe,
Pratsinis Sotiris E.
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201303416
Subject(s) - materials science , photothermal therapy , irradiation , nanoparticle , plasmon , superparamagnetism , laser , absorption (acoustics) , optoelectronics , nanotechnology , optics , magnetization , composite material , physics , quantum mechanics , magnetic field , nuclear physics
Tumor ablation by thermal energy via the irradiation of plasmonic nanoparticles is a relatively new oncology treatment. Hybrid plasmonic‐superparamagnetic nanoaggregates (50–100 nm in diameter) consisting of SiO 2 ‐coated Fe 2 O 3 and Au (≈30 nm) nanoparticles were fabricated using scalable flame aerosol technology. By finely tuning the Au interparticle distance using the SiO 2 film thickness (or content), the plasmonic coupling of Au nanoparticles can be finely controlled bringing their optical absorption to the near‐IR that is most important for human tissue transmittance. The SiO 2 shell facilitates also dispersion and prevents the reshaping or coalescence of Au particles during laser irradiation, thereby allowing their use in multiple treatments. These nanoaggregates have magnetic resonance imaging (MRI) capability as shown by measuring their r2 relaxivity while their effectiveness as photothermal agents is demonstrated by killing human breast cancer cells with a short, four minute near‐IR laser irradiation (785 nm) at low flux (4.9 W cm ‐2 ).