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Bright and Photostable Organic Fluorescent Dots with Aggregation‐Induced Emission Characteristics for Noninvasive Long‐Term Cell Imaging
Author(s) -
Qin Wei,
Li Kai,
Feng Guangxue,
Li Min,
Yang Zhiyong,
Liu Bin,
Tang Ben Zhong
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201302114
Subject(s) - quantum dot , materials science , fluorescence , aggregation induced emission , nanotechnology , biocompatibility , stokes shift , biophysics , optoelectronics , luminescence , optics , biology , physics , metallurgy
Efficient long‐term cell tracing in a noninvasive and real‐time manner is of great importance to understand genesis, development, invasion, and metastasis of cancerous cells. Cell penetrating organic dots with aggregation‐ induced emission (AIE) characteristics are successfully developed as long‐term cell trackers. The AIE dots enjoy the advantages of high emission efficiency, large Stokes shift, good biocompatibility, and high photostability, which ensure their good performance in long‐term non‐invasive in vitro cell tracing. Moreover, it is the first report that AIE dots exhibit certain permeability to cellular nucleus, making them attractive potential candidates for nucleus imaging. The AIE dots display superior performance compared to their counterparts of inorganic quantum dots, opening a new avenue in the development of fluorescent probes for monitoring biological processes.