NIR‐Triggered Synergic Photo‐chemothermal Therapy Delivered by Reduced Graphene Oxide/Carbon/Mesoporous Silica Nanocookies | Zendy

Chen YuWei | Zendy; Chen PoJung | Zendy; Hu ShangHsiu | Zendy; Chen IWei | Zendy; Chen SanYuan | Zendy

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NIR‐Triggered Synergic Photo‐chemothermal Therapy Delivered by Reduced Graphene Oxide/Carbon/Mesoporous Silica Nanocookies

Author(s) -

Chen YuWei,

Chen PoJung,

Hu ShangHsiu,

Chen IWei,

Chen SanYuan

Publication year - 2014

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.201301763

Subject(s) - materials science , photothermal therapy , graphene , camptothecin , drug delivery , mesoporous silica , oxide , nanotechnology , mesoporous material , coating , carbon fibers , chemical engineering , organic chemistry , composite material , catalysis , chemistry , composite number , metallurgy , engineering

A novel photo‐responsive drug carrier that doubles as a photothermal agent with a nanocookie‐like structure is constructed by coating amorphous carbon on a mesoporous silica support self‐assembled on a sheet of reduced graphene oxide. With a large payload (0.88 mmolg −1 ) of a hydrophobic anticancer drug, (S)‐(+)‐camptothecin (CPT), nanocookies simultaneously provide a burst‐like drug release and intense heat upon near‐infrared exposure. Being biocompatible yet with a high efficiency for cell uptake, nanocookies have successfully eradicated subcutaneous tumors in 14 days following a single 5 min NIR irradiation without distal damage. These results demonstrate that the nanocookie is an excellent new delivery platform for local, on‐demand, NIR‐responsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.

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