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On‐Chip Fabrication of Paclitaxel‐Loaded Chitosan Nanoparticles for Cancer Therapeutics
Author(s) -
Majedi Fatemeh Sadat,
HasaniSadrabadi Mohammad Mahdi,
VanDersarl Jules John,
Mokarram Nassir,
HojjatiEmami Shahirar,
Dashtimoghadam Erfan,
Bonakdar Shahin,
Shokrgozar Mohammad Ali,
Bertsch Arnaud,
Renaud Philippe
Publication year - 2014
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201301628
Subject(s) - materials science , chitosan , paclitaxel , fabrication , nanotechnology , nanoparticle , chip , cancer , chemical engineering , medicine , engineering , electrical engineering , alternative medicine , pathology
The use of solvent‐free microfluidics to fine‐tune the physical and chemical properties of chitosan nanoparticles for drug delivery is demonstrated. Nanoparticle self‐assembly is driven by pH changes in a water environment, which increases biocompatibility by avoiding organic solvent contamination common with traditional techniques. Controlling the time of mixing (2.5–75 ms) during nanoparticle self‐assembly enables us to adjust nanoparticle size and surface potential in order to maximize cellular uptake, which in turn dramatically increases drug effectiveness. The compact nanostructure of these nanoparticles preserves drug potency better than previous nanoparticles, and is more stable during long‐term circulation at physiological pH. However, when the nanoparticles encounter a tumor cell and the associated drop in pH, the drug contents are released. Moreover, the loading efficiency of hydrophobic drugs into the nanoparticles increases significantly from previous work to over 95%. The microfluidic techniques used here have applications not just for drug‐carrying nanoparticle fabrication, but also for the better control of virtually any self‐assembly process.