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Multifunctional Up‐Converting Nanocomposites with Smart Polymer Brushes Gated Mesopores for Cell Imaging and Thermo/pH Dual‐Responsive Drug Controlled Release
Author(s) -
Zhang Xiao,
Yang Piaoping,
Dai Yunlu,
Ma Ping'an,
Li Xuejiao,
Cheng Ziyong,
Hou Zhiyao,
Kang Xiaojiao,
Li Chunxia,
Lin Jun
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201300136
Subject(s) - nanocarriers , materials science , doxorubicin hydrochloride , mesoporous silica , drug delivery , polymer , smart polymer , controlled release , nanotechnology , nanocomposite , lower critical solution temperature , chemical engineering , copolymer , mesoporous material , doxorubicin , organic chemistry , chemistry , medicine , surgery , engineering , chemotherapy , composite material , catalysis
Multifunctional nanocarriers based on the up‐conversion luminescent nanoparticles of NaYF 4 :Yb 3+ /Er 3+ core (UCNPs) and thermo/pH‐coupling sensitive polymer poly[( N ‐isopropylacrylamide)‐ co ‐(methacrylic acid)] (P(NIPAm‐ co ‐MAA)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. The as‐synthesized hybrid nanospheres UCNPs@mSiO 2 ‐P(NIPAm‐ co ‐MAA) show bright green up‐conversion fluorescence under 980 nm laser excitation and the thermo/pH‐sensitive polymer is active as a “valve” to moderate the diffusion of the embedded drugs in‐and‐out of the pore channels of the silica container. The anticancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO 2 ‐P(NIPAm‐ co ‐MAA) nanospheres and the composite drug delivery system (DDS) shows a low level of leakage at low temperature/high pH values but significantly enhanced release at higher temperature/lower pH values, exhibiting an apparent thermo/pH controlled “on‐off” drug release pattern. The as‐prepared UCNPs@mSiO 2 ‐P(NIPAm‐ co ‐MAA) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. The reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli‐responsive controlled drug delivery.