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Drug Delivery: Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice (Adv. Funct. Mater. 20/2012)
Author(s) -
Godin Biana,
Chiappini Ciro,
Srinivasan Srimeenakshi,
Alexander Jenolyn F.,
Yokoi Kenji,
Ferrari Mauro,
Decuzzi Paolo,
Liu Xuewu
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201290121
Subject(s) - materials science , microfabrication , scanning electron microscope , porous silicon , biodistribution , nanoparticle , nanotechnology , drug delivery , silicon , porosity , fabrication , biomedical engineering , optoelectronics , composite material , chemistry , pathology , medicine , alternative medicine , biochemistry , in vitro
Porous silicon (pSi) disks, rendered from a scanning electron microscopy (SEM) image, are shown on the background of an immuno‐histochemistry fluorescent microscopy image from a breast tumor. On page 4225 , Biana Godin, Xuewu Liu, and co‐workers describe the microfabrication of discoidal pSi nanoparticles with precisely controlled morphologies made by direct photolithographic patterning and demonstrate the geometry‐dependent, preferable accumulation of the pSi disks over spherical nanoparticles in orthotopic murine models of breast cancer.