Biomedical Applications: Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica (Adv. Funct. Mater. 1/2012) | Zendy

Lebold Timo | Zendy; Schlossbauer Axel | Zendy; Schneider Katrin | Zendy; Schermelleh Lothar | Zendy; Leonhardt Heinrich | Zendy; Bein Thomas | Zendy; Bräuchle Christoph | Zendy

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Biomedical Applications: Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica (Adv. Funct. Mater. 1/2012)

Author(s) -

Lebold Timo,

Schlossbauer Axel,

Schneider Katrin,

Schermelleh Lothar,

Leonhardt Heinrich,

Bein Thomas,

Bräuchle Christoph

Publication year - 2012

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.201290005

Subject(s) - materials science , oligonucleotide , mesoporous silica , nanometre , nanotechnology , surface modification , drug delivery , mesoporous material , diffusion , chemical engineering , dna , organic chemistry , chemistry , biochemistry , physics , engineering , composite material , thermodynamics , catalysis

Mesoporous silica particles represent a novel, highly versatile class of drug‐delivery systems. On page 106 , Thomas Bein, Christoph Bräuchle, and co‐workers utilize these materials as a host for the incorporation of short oligonucleotides as model gene therapeutics. The diffusion of a labelled oligo‐nucleotide through a nanometer‐sized silica pore is shown. Organic functionalization of the silica pore system offers a means to control oligonucleotide mobility and stability.

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