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Biomedical Applications: Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica (Adv. Funct. Mater. 1/2012)
Author(s) -
Lebold Timo,
Schlossbauer Axel,
Schneider Katrin,
Schermelleh Lothar,
Leonhardt Heinrich,
Bein Thomas,
Bräuchle Christoph
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201290005
Subject(s) - materials science , oligonucleotide , mesoporous silica , nanometre , nanotechnology , surface modification , drug delivery , mesoporous material , diffusion , chemical engineering , dna , organic chemistry , chemistry , biochemistry , physics , engineering , composite material , thermodynamics , catalysis
Mesoporous silica particles represent a novel, highly versatile class of drug‐delivery systems. On page 106 , Thomas Bein, Christoph Bräuchle, and co‐workers utilize these materials as a host for the incorporation of short oligonucleotides as model gene therapeutics. The diffusion of a labelled oligo‐nucleotide through a nanometer‐sized silica pore is shown. Organic functionalization of the silica pore system offers a means to control oligonucleotide mobility and stability.