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A Stiff Injectable Biodegradable Elastomer
Author(s) -
Mizrahi Boaz,
Shankarappa Sahadev A.,
Hickey Julia M.,
Dohlman Jenny C.,
Timko Brian P.,
Whitehead Kathryn A.,
Lee JungJae,
Langer Robert,
Anderson Daniel G.,
Kohane Daniel S.
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201202433
Subject(s) - materials science , biocompatibility , elastomer , drug delivery , peg ratio , elastic modulus , self healing hydrogels , chemical engineering , dopamine , biomedical engineering , composite material , nanotechnology , polymer chemistry , medicine , finance , neuroscience , economics , engineering , metallurgy , biology
Injectable materials often have shortcomings in mechanical and drug‐eluting properties that are attributable to their high water contents. A water‐free, liquid four‐armed PEG modified with dopamine end groups is described which changes from liquid to elastic solid by reaction with a small volume of Fe 3+ solution. The elastic modulus and degradation times increase with increasing Fe 3+ concentrations. Both the free base and the water‐soluble form of lidocaine can be dissolved in the PEG 4 ‐dopamine and released in a sustained manner from the cross‐linked matrix. PEG 4 ‐dopamine is retained in the subcutaneous space in vivo for up to 3 weeks with minimal inflammation. This material's tailorable mechanical properties, biocompatibility, ability to incorporate hydrophilic and hydrophobic drugs and release them slowly are desirable traits for drug delivery and other biomedical applications.