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Biomimetic Membrane System Composed of a Composite Interpenetrating Hydrogel Film and a Lipid Bilayer
Author(s) -
Stidder Barry,
Alcaraz JeanPierre,
Liguori Lavinia,
Khalef Nawel,
Bakri Aziz,
Watkins Erik B.,
Cinquin Philippe,
Martin Donald K.
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201200751
Subject(s) - materials science , polyelectrolyte , membrane , bilayer , lipid bilayer , adsorption , chemical engineering , diffusion , polyelectrolyte adsorption , agarose , nanotechnology , polymer , composite material , chromatography , organic chemistry , chemistry , biochemistry , physics , engineering , thermodynamics
A simple way to form an interpenetrating hydrogel (IPH) by combining a layer‐by‐layer polyelectrolyte membrane with agarose is reported. The formed IPH membrane is more robust and easily manipulated compared to a polyelectrolyte membrane with the same number of layers. The IPH has good diffusion characteristics and retains the advantageous surface charge from the polyectrolyte composition that facilitates the adsorption of a stable lipid bilayer. The stable adsorption of a lipid bilayer on the IPH creates a biomimetic membrane system that is optimized for utilization in a diffusion chamber.