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Superparamagnetic Nanostructures for Off‐Resonance Magnetic Resonance Spectroscopic Imaging
Author(s) -
Choo Eugene Shi Guang,
Peng Erwin,
Rajendran Reshmi,
Chandrasekharan Prashant,
Yang ChangTong,
Ding Jun,
Chuang KaiHsiang,
Xue Junmin
Publication year - 2013
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201200275
Subject(s) - superparamagnetism , materials science , magnetic resonance imaging , nanoparticle , nuclear magnetic resonance , biocompatibility , nanostructure , nanotechnology , colloid , spectroscopy , mri contrast agent , resonance (particle physics) , magnetic field , chemical engineering , magnetization , radiology , medicine , physics , particle physics , quantum mechanics , engineering , metallurgy
This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom‐up approach. The composite nanoparticles are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons, which can be demonstrated in MR spectroscopy and imaging to be different from the bulk pool. Moreover, the particles exhibit excellent colloidal stability in aqueous media and good cell biocompatibility. Hence, these particles are potentially useful as biomarkers by taking advantage of the positive contrast effects produced in MRI.