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Biomedical Applications: Multifunctionalized Electrospun Silk Fibers Promote Axon Regeneration in the Central Nervous System (Adv. Funct. Mater. 22/2011)
Author(s) -
Wittmer Corinne R.,
Claudepierre Thomas,
Reber Michael,
Wiedemann Peter,
Garlick Jonathan A.,
Kaplan David,
Egles Christophe
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201190103
Subject(s) - silk , regeneration (biology) , axon , phalloidin , chemistry , anatomy , materials science , microbiology and biotechnology , biology , cell , composite material , biochemistry , cytoskeleton
On page 4232 , Christophe Egles and co‐workers have designed electrospun silk fibers biofunctionalized with growth factors that promote axon regeneration in the central nervous system. The inside cover shows a merged image of the autofluorescent silk fibers (green), phalloidin labeling of the actin filaments (red), and DAPI nuclear staining (blue) in a retinal ganglion cell. The growth cones of the cells elongate along the silk fibers and change direction at silk crossroads. Nerve cells exhibit longer axonal growth when in contact with biofunctionalized fibers in comparison with unfunctionalized silk.