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Drug Delivery: Paclitaxel‐Loaded Polymer Nanoparticles for the Reversal of Multidrug Resistance in Breast Cancer Cells (Adv. Funct. Mater. 22/2011)
Author(s) -
Lee Yeonju,
Graeser Ralph,
Kratz Felix,
Geckeler Kurt E.
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201190102
Subject(s) - paclitaxel , materials science , multiple drug resistance , endocytosis , drug delivery , nanoparticle , p glycoprotein , drug , cancer cell , drug resistance , breast cancer , cancer , pharmacology , nanotechnology , cancer research , medicine , cell , chemistry , biology , biochemistry , microbiology and biotechnology
Water‐soluble paclitaxel‐loaded polymer nanoparticles, synthesized by Kurt E. Geckeler and coworkers on page 4211 , show a significant reversal of the chemoresistance in drug‐resistant human breast cancer cell lines. The front cover illustrates different cellular interaction patterns between the paclitaxel (red) and the polymer nanoparticles (blue spheres containing red particle) on the drug‐resistant P‐glycoprotein (purple) expressing human breast cancer cells. Paclitaxel is continuously transported by the P‐glycoprotein, however, the paclitaxel‐loaded nanoparticles taken up by endocytosis are able to reverse the multidrug resistance by bypassing the P‐glycoprotein.